The Delaware Division of Public Health (DPH) is sending this health advisory to notify health care providers of a detection of measles found in sewage samples through routine wastewater testing in Lewes, Delaware. The positive samples were collected on Wednesday, April 22, 2026 and Monday, April 27, 2026. Detection of measles in wastewater does not represent an official measles case, and this comes at a time when no active measles infections have been reported in Delaware. However, DPH urges health care providers to maintain heightened awareness for patients with symptoms compatible with measles and to continue to promote vaccination. This detection could mean that there was at least one person with a measles infection present or traveling through Lewes around the time of this detection.

 

Summary

·       Delaware conducts wastewater surveillance for wild-type measles virus to detect early, silent community transmission, often appearing before clinical cases are reported.

·       Measles is very contagious and can cause serious health complications.

·       Measles symptoms appear seven to 14 days after contact with the virus.

·       Common measles symptoms include high fever (may spike to more than 104° F); cough; runny nose; red, watery eyes (conjunctivitis or pink eye), and rash.

·       Anyone who is not protected against measles is at risk.

·       Two doses of measles, mumps, and rubella (MMR) vaccine provide the best protection against measles. 

·       Measles can cause serious health complications, especially in children younger than 5 years of age. Common complications are ear infections and diarrhea. Serious complications include pneumonia, encephalitis (swelling of the brain) and in some cases, death.

·       Measles is reportable in Delaware. All suspected cases and positive laboratory reports should be reported immediately to DPH by emailing reportdisease@delaware.gov, by calling the Office of Infectious Disease Epidemiology at 1-888-295-5156, or by sending electronically through the Delaware EpiLab Insight Disease Surveillance System.

 

Background

Wastewater-based surveillance for measles detects virus RNA (shed by infected individuals) in sewage, providing an early warning system for community transmission, often detecting outbreaks before clinical cases are reported. This method acts as a sentinel system, facilitating public health action, such as promoting vaccination and alerting health care providers, particularly as measles cases rise across the United States and globally. Delaware conducts wastewater surveillance for wild-type measles virus to detect early, silent community transmission, often appearing before clinical cases are reported.

Measles is a highly contagious virus that causes an acute respiratory illness. If one person has measles, 9 to 10 people around them will also become infected unless they are vaccinated against measles. Measles can be serious in all age groups. However, several groups are more likely to suffer from measles complications, including children younger than 5 years of age, adults older than 20 years of age, pregnant women, and people with compromised immune systems, such as leukemia or HIV infection. Measles lives in the nose and throat mucus of an infected person. It can spread to others through coughing and sneezing. If other people breathe the contaminated air or touch the infected surface, then touch their eyes, noses, or mouths, they become infected.

 

Clinical Characteristics

Health care professionals (HCPs) are recommended to:

·       Consider measles as a diagnosis in anyone with febrile illness and clinically compatible symptoms (e.g. rash, cough, coryza, or conjunctivitis) who has recently traveled abroad or to outbreak regions.

·       Immediately notify DPH about any suspected case of measles to ensure rapid testing and investigation. Contact the Office of Infectious Disease Epidemiology during regular business hours (302-744-4990) or the state’s 24-hour reporting line at 1-888-295-5156 outside of normal business hours.

·       Recommend MMR vaccine for patients who are unvaccinated or not fully vaccinated.

·       Do not allow patients with suspected measles to remain in the waiting room or other common areas of the health care facility; isolate patients with suspected measles immediately, ideally in a single-patient airborne infection isolation room (AIIR), if available. If an AIIR is not available, isolate patients in a single-patient room with a closed door.

·       Follow CDC’s testing recommendations and collect either a nasopharyngeal swab or urine specimen for Reverse Transcription Polymerase Chain Reaction (RT-PCR) as well as a blood specimen for serology from all patients with clinical features compatible with measles. RT-PCR is available at many state public health laboratories and through the APHL/CDC Vaccine Preventable Disease Reference Centers.

·       Ensure all patients are up to date on MMR vaccine and other recommended vaccines.

·       For people traveling abroad, CDC recommends that all U.S. residents older than six months be protected from measles and receive MMR vaccine, if needed, prior to departure. 

If you suspect patient exposure, either administer MMR vaccine within 72 hours of initial measles exposure or immunoglobulin (IG) within six days of exposure. The MMR vaccine and IG provide post-exposure prophylaxis (PEP) to prevent measles or modify the clinical course of disease among susceptible people. For vaccine eligible people aged ≥12 months exposed to measles, administration of MMR vaccine is preferable to using IG, if administered within 72 hours of initial exposure. The following patient groups are at risk for severe disease and complications from measles and should receive IG: infants aged <12 months, pregnant women without evidence of measles immunity, and severely immunocompromised people. IG can be administered to other people who do not have evidence of measles immunity, but priority should be given to people exposed in settings with intense, prolonged, close contact (e.g., household, daycare, and classroom). Do not administer MMR vaccine and IG simultaneously, as this practice invalidates the vaccine.

 

Recommendations for Prevention

The best way to protect against measles is with the measles, mumps, and rubella (MMR) vaccine. MMR is safe and effective – serious reactions are extremely rare. Two doses of MMR vaccine are about 97% effective at preventing measles; one dose is about 93% effective. Talk to your patients about the MMR vaccine, especially if they are planning to travel. 

 

Laboratory Testing

Real-time RT-PCR (rRT-PCR): Nasopharyngeal swabs for PCR testing are preferred over urine specimens. PCR specimens can be requested to be tested at the Delaware Public Health Laboratory (DPHL). Contact the Office of Infectious Disease Epidemiology during regular business hours (302-744-4990) or the state’s 24-hour reporting line at 1-888-295-5156 outside of normal business hours to request approval for testing at the DPHL.

For serology, collect the first (acute phase) serum specimen (IgM and IgG) as soon as possible upon suspicion of measles disease. If the acute-phase serum specimen collected ≤3 days after rash onset is negative and the case has a negative result for real-time RT-PCR (rRT-PCR), or one was not done, a second serum specimen collected three to 10 days after symptom onset is recommended because the IgM response may not be detectable until three days after symptom onset. As of February 2026, serology testing is not currently available at DPHL, but DPHL may be able to facilitate testing through a partner, if needed.  

 HCPs should use respiratory protection (i.e., a respirator), that is at least as protective as a fit-tested, NIOSH-certified disposable N95 filtering facepiece respirator, regardless of presumptive evidence of immunity, upon entry to the room or care area of a patient with known or suspected measles.

DPHL offers nasopharyngeal PCR test for measles. Non-PCR testing is not available at DPHL Serology must be sent to a commercial laboratory. To order a nasopharyngeal PCR test for measles through DPHL, an ordering Provider or Infection Preventionist must first contact the DPH Office of Infectious Disease Epidemiology for testing approval at 302-744-4990. Also fill out the test requisition. Specimens not labeled on the tube, or without two unique identifiers (Name, date-of-birth) will be rejected. After the DPH Office of Infectious Disease Epidemiology (OIDE) approves, testing sample pickup is coordinated between DPHL and OIDE. Once sample reaches the laboratory, testing takes four to eight working hours. Processing time may change if the volume of tests continues to increase.

 

Reporting

Delaware physicians, laboratories, and other health care providers are required by regulations

to report patients with measles to OIDE immediately upon identification. Do not wait for test results to be available to contact OIDE. Early reporting enables appropriate public health follow-up for your patients, helps identify outbreaks, and provides a better understanding of disease trends in Delaware. Cases can be reported to the DPH Office of Infectious Disease Epidemiology (OIDE) by calling 302-744-4990 (normal business hours) or 1-888-295-5156 (outside of normal business hours). Urgent notification by phone is preferred. You may also complete a Notifiable Disease Report PDF Form and fax the form to DPH at 302-622-4149 or email to: reportdisease@delaware.gov. The form can be found online at: https://dhss.delaware.gov/dph/dpc/rptdisease/.

 

More Information

Clinical Overview of Measles

Interim Infection Prevention and Control Recommendations for Measles in Healthcare Settings

Plan for Travel – Measles

Laboratory Testing for Measles

Measles Serology Testing